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RUFY3 and RUFY4 are ARL8 effectors that couple lysosomes to dynein-dynactin
The small GTPase ARL8 associates with lysosomes and recruits several effectors that mediate coupling to kinesins for anterograde transport, as well as tethering for eventual fusion with other organelles. Herein we report the identification of the "RUN- and FYVE-domain-containing" proteins RUFY3 and RUFY4 as novel ARL8 effectors that couple lysosomes to dynein-dynactin for retrograde transport. Using various biochemical approaches, we find that RUFY3/4 interact with both GTP-bound ARL8 anddoi:10.21203/rs.3.rs-469512/v1 fatcat:vr6z7txfu5ahdgsjcvrmhkpwrm