2021 International Journal of Biology Pharmacy and Allied Sciences  
Brain organoids which is also known Cerebral organoids is a self assembled threedimensional structure which is composed of millions of cells that resembles the cellular organization, transcriptional and epigenetic signature of a developing human brain. Key features of early human brains development at molecular, cellular, structural and functional levels are mimicked by brain organoids but the formation of distinct cortical neuronal layers, gyrification and the establishment of complex neuronal
more » ... circuitry are not fully recapitulated. The main aim in this study was that various features of brain organoids, their application and development are analyzed and recent advances in generation of human brain organoids are discussed and reviewed. This Review was done based on the articles obtained from Various platforms like PubMed, PubMed central and Google scholar. They were collected with a restriction in time basis from 2000 -2020. The inclusion criteria were original research papers, review articles. In vitro studied among various conditions and articles that contain pros and cons. Exclusion criteria came into account for retracted articles and articles of other languages. All the articles were selected based on Brain organoids. Brain organoids help
doi:10.31032/ijbpas/2021/10.8.1006 fatcat:hy3ytndstbbntjp46yuakkd2jy