When is a further clinical trial justified?

M. L. Ferreira, R. D. Herbert, M. J. Crowther, A. Verhagen, A. J. Sutton
2012 The BMJ (British Medical Journal)  
High quality randomised trials provide unbiased estimates of the effects of health interventions, but the findings of a single trial are rarely conclusive. Usually data from several similar trials must be pooled together to draw firm conclusions about the effectiveness of an intervention. This article considers how to determine whether data from existing trials are conclusive and, if not, whether a further trial is justified. Manuela L Ferreira research fellow 1 , Robert D Herbert professor 2 ,
more » ... Michael J Crowther research associate 3 , Arianne Verhagen associate professor 4 , Alex J Sutton professor of medical statistics 3
doi:10.1136/bmj.e5913 pmid:22977141 fatcat:r2nenpkgxzg4vb5j5ezzi5x5mi