Time to recognize zebrafish 'affective' behavior

Allan V. Kalueff, Philippe Vernier, Evan J. Kyzar, Caio Maximino, Keith Tierney, Michael Gebhardt, Merlin Lange, Suresh Jesuthasan, Adam Michael Stewart, Stephan C.F. Neuhauss, Kyle Robinson, William Norton (+6 others)
2012 Behaviour  
Widely used in biomedical research, zebrafish (Danio rerio) are steadily gaining popularity as a model organism for studying neurobehavioral phenomena. Here, we focus on to the growing spectrum of zebrafish behavioral phenotypes and the 'bigger' biological problems these models help to address. Emphasizing the developing potential of zebrafish as a model organism in biological psychiatry, we discuss several questions related to this field: Do zebrafish have 'emotional'-like behaviors? What are
more » ... ehaviors? What are their neural circuits, biomarkers, and ontogenetic origins? And, finally, how can we use this knowledge to build translational bridges to understand human emotions, motivation and personality? Representing a joint effort of several established neurobehavioral laboratories, this Time to recognize zebrafish 'affective' behavior article outlines the mounting evidence to support emotionality in zebrafish and other fishes. This conclusion is important to justify the validity of zebrafish 'affective' paradigms and their utility for basic/translational research of normal and pathological behaviors.
doi:10.1163/1568539x-00003030 fatcat:mfcbx7iaq5fk7hrs35jgz4o3o4