Overview of Drug Resistant Mycobacterium tuberculosis

Anurag Rai, Taiyaba Khan
2018 International Journal of Life-Sciences Scientific Research  
MDR-TB is a global occurrence that poses a serious threat. Tuberculosis (TB) is still the leading cause of death from a single and curable infectious disease. It is the second-most common cause of death from infectious disease (after those due to HIV/AIDS). Its situation is worsened by the presence of multidrug-resistant (MDR) strains of M. tuberculosis. In ancient time, it was considered a curse. Tuberculosis started to reemerge in the early 1990s. The completion of the first whole genome
more » ... nce of M. tuberculosis was in 1998. Multi drug resistant (MDR)-TB is caused by strains of M. tuberculosis that resistant to at least rifampicin and isoniazid. Worldwide India is the country with the highest-burden of both TB and MDR-TB. Isolation of MTB on solid media followed by subsequent DST on solid media is easy to perform in the lab. They are time-consuming classical laboratory tests methods. So the molecular method is preferable to detect MTB. Different types of tool are available to detect MDR-TB, XDR-TB. Now-a-days, there are three major commercial alternatives available and they are: GeneXpert, line probe assays (LPA) and Nucleic acid amplification tests (NAAT). The treatment takes too long, many patients are unable to tolerate the combination, and there is a growing threat from multidrug-resistant (MDR) and extremely drug-resistant (XDR)-TB. Reliable and timely detection of drugresistant TB is needed.
doi:10.21276/ijlssr.2018.4.3.9 fatcat:64dy4st5ebhphmgwkwgra4sodi