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Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management
2019
Scientific Reports
Improvements in the survival of breast cancer patients have led to the emergence of bone health and pain management as key aspects of patient's quality of life. Here, we used a female rat MRMT-1 model of breast cancer-induced bone pain to compare the effects of three drugs used clinically morphine, nabilone and zoledronate on tumor progression, bone remodeling and pain relief. We found that chronic morphine reduced the mechanical hypersensitivity induced by the proliferation of the luminal B
doi:10.1038/s41598-019-56622-5
pmid:31882872
pmcid:PMC6934511
fatcat:34unamcaw5banmjelqakbjbea4