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Peptide Inhibitors of the CobratoxinNicotinic Acetylcholine Receptor Interaction
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unpublished
Venomous snakebites cause >100 000 deaths every year, in many cases via potent depression of human neuromuscular signaling by snake α-neurotoxins. Emergency therapy still relies on antibody-based antivenom, hampered by poor access, frequent adverse reactions, and cumbersome production/purification. Combining high-throughput discovery and subsequent structure−function characterization, we present simple peptides that bind α-cobratoxin (α-Cbtx) and prevent its inhibition of nicotinic
doi:10.1021/acs.jmedchem.0c01202.s001
fatcat:cpys7ifisba25ecathfrw2al2m