α-Glucosidase inhibitory and cytotoxic botryorhodines from mangrove endophytic fungus Trichoderma sp. 307

Liuhong Zhang, Shah Iram Niaz, Zhen Wang, Yonghong Zhu, Yongcheng Lin, Jing Li, Lan Liu
2017 Figshare  
One new depsidone, botryorhodine H (1), together with three known analogues, botryorhodines C, D and G (2–4), were obtained from the mangrove endophytic fungus Trichoderma sp. 307 by co-culturing with Acinetobacter johnsonii B2. Structures were determined by 1D and 2D NMR analyses and high-resolution mass spectrum. Compounds 1–3 showed α-glucosidase inhibitory activity with IC50 ranging from 8.1 to 11.2 μM, and compound 1 exhibited potent cytotoxicity against rat prolactinoma MMQ and rat
more » ... MMQ and rat pituitary adenoma GH3 cell lines (IC50 = 3.09 and 3.64 μM).
doi:10.6084/m9.figshare.5492725 fatcat:afhbh7ix3zfdpad34gb4h7iu7y