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Dextran 40 (Rheomacrodex) or Polygeline (Haemaccel) as an epidural patch for post dural puncture headache: a neurotoxicity study in a rat model of Dextran 40 and Polygeline injected intrathecally
European Journal of Anaesthesiology
and objective: Although an epidural autologous blood patch is considered the most effective treatment for post dural puncture headache, which sometimes occurs following spinal or inadvertent spinal anaesthesia, there remains a need for alternative materials for epidural patches. We investigated the potential neurotoxicity of Dextran 40 (Rheomacrodex) and Polygeline (Haemaccel) used for this purpose in a rat model. Methods: Repeated boluses of 10% Dextran 40, 3.5% Polygeline or 0.9% saline weredoi:10.1017/s0265021506001037 pmid:16836769 fatcat:cyhp4tjzdbaync4ojbuia4ewfe