Av/an KINOSHITA2 l\/lASAF'U1\/II TAMWAKI3, HIDEAKI TADA', l\/lICHIO SHIROZUl, l 3 3 Toau NAKANO , KE1 TAsH1Ro" and TASUKU I-1oNJo' ABSTRACT §tromal cell-derived receptor-1 (SDR-1) at and /3, also called gp55 and gp65, belong to the immunoglobulin (lg) superfamily. Rabbit antisera specific to SDR-1 p' and those recognizing both Q' and p' forms of SDR-1 were raised to study regional distributions of SDR-la and 5 in the adult rodent brain. lmmunohistochemical studies of adult rat brains with

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... antibodies revealed a granular pattern of staining distributed within neuropils. SDR-1 /1' form like immunoreactivity (/5'-Ll) was detected in limited regions, namely the glomerulus of the olfactory bulb and the superficial layers (layers ll, Ill) of the cerebral cortex, whereas er/3-Ll was found in the olfactory tubercle, cerebral contex, hippocampus, thalamus, midbrain, and molecular layer in the cerebellum, suggesting wider distribution of SDR-1 an The SDR1 gene is highly conserved from Xenopus to human. The human SDR-1 cDNA was isolated and the human SDR] gene was mapped to chromosome 15q22 by fluorescence in sitar hybridization.