Biological Findings During Sequential Thrombolytic Treatments With Defibrase, Lysyl-Plasxinogen and Urokinase

P. Griguer, PH. Dusson, Mireille Brochier
1979 VIIth International Congress on Thrombosis and Haemostasis   unpublished
Biological changes induced by a snake venom (Defibrase - DEF) infused prior to a thrombolytic treatment are studied in a series of 35 pulmonary embolism (P. E) and/or deep vein thrombosis (D. V. T). Group I (n : 13) includes old PE and or D.V.T (14 ± 6 days old) in which DEF infusion is performed prior to thrombolytic treatment ; Group II (n : 22) includes recent P. E and/or D.V.T. A first treatment with Lysyl-Plasminogen (Lys-Plg) and Urokinase (UK) with poor or insufficient results is
more » ... by DEF infusions just before a second thrombolytic treatment. The results of these treatments controlled angiographically (before and 24 hours after the end of the last UK infusion) have shown that a better revascularisation could be obtained even in old PE, when Defibrase is given prior to thrombolytic treatment. During the DSF infusions, we observed a decrease of fibrinogen m less than 36 hours (to a mean level of 0,20 to 0,30 g/l). The % of circulating plasminogen consumption is 48.22 % ± 22, and a rapid drop of the fast reacting antiplasmin level (F.R. antipl) occurs (from 77,5 % ± 30 to 12,9 % ± 7,6) During the thrombolytic treatment following DEF, we observed an enhancement of fibrinolytic activity. From these data we may conclude that DEF is able to determine plasminantiplasmin complexes and a large drop of the fast antiplasmin level, in the blood
doi:10.1055/s-0039-1684855 fatcat:ultuglqwz5bejhmayo7qvawllm