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The lack of effective therapeutics for Coxsackievirus B 4 (CVB 4 ) infection underscores the importance of finding novel antiviral compounds. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is one of the natural anthraquinone derivatives obtained from the root and rhizome of Polygonum cuspidatum. In the present study, the possibility of using emodin as a potential antiviral to treat CVB 4 infection was explored in vitro and in mice. Emodin reduced CVB 4 entry and replication on Hep-2 cells in adoi:10.3390/molecules181011842 pmid:24071990 fatcat:5m3ftu5rkjbnzmvmvaxk3fsyzm