Electrospun SF/PLGA/ICG Composite Nanofibrous Membranes for Potential Wound Healing and Tumor Therapy

Jiale Zhou, Hai Wang, Haiyan Wu, Dongwei Lan, Yan Peng, Zhi Li, Fangyin Dai
2022 Processes  
Indocyanine green (ICG) is a near-infrared (NIR) organic reagent for clinical bioimaging and phototherapy. It is a suitable photosensitizer for photodynamic antimicrobial chemotherapy (PACT). In this study, various ICG-loaded nanofibrous membranes were prepared. The water vapor transmission rate (WVTR) of SF/PLGA/20ICG was 3040.49 ± 157.11 g·m−2 day−1, which allowed the maintenance of a humid environment above the wound. The growth inhibition rates for S. aureus and E. coli were 91.53% and
more » ... %, respectively. The nanofibrous membranes exhibited excellent antimicrobial performance. Cellular experiments showed that the nanofibrous membranes have good cytocompatibility and antitumor efficacy. SF/PLGA/20ICG showed good potential for application in wound healing and cancer therapy.
doi:10.3390/pr10050850 doaj:78f003923b5041119cc0f9f75533cbd3 fatcat:2taptpef7rcfzjjtufxubkwri4