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Vascular lesions produced by renal cortical extracts of spontaneously hypertensive rats (SHR)

I Nishimori, N Miyagawa, J Miyazaki, T Takagi
1978 Japanese Heart Journal  

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From the renal cortical extracts of spontaneously hypertensive rats (SHR) and normal rats, the fraction without pressor effect but with vascular necrotizing effect (F3) and the fraction with pressor effect (F4) were isolated and compared. The pressor effect of F4 showed no difference between SHR and normal rats. Vascular lesions of the mesentery and pancreas produced by renal extracts were examined light microscopically and electron microscopically to compare the vascular necrotizing effects of
more » ... renal extracts. Both F3 and F4 of SHR showed more intensive vascular necrotizing effect than renal extracts of normal rats. It was speculated that F4 of SHR contains some vascular necrotizing substance without pressor effect.
pmid:731923 fatcat:pukhpfuinvfbpoxmnguksyodzi
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I Nishimori, N Miyagawa, J Miyazaki, T Takagi. "Vascular lesions produced by renal cortical extracts of spontaneously hypertensive rats (SHR)." Japanese Heart Journal 19.4 (1978) 659