Controlled drug carriers are important for the treatment of chronic illnesses. They are classified based on their physicochemical properties, release mechanism and preparation methods employed. Mesoporous materials with surface functionalization have attracted many researchers for drug carrier applications, among them amine functionalized mesoporous materials are largely studied. A disadvantage is costly organic templates are used during the hydrothermal synthesis of the mesoporous materials to

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... control both the pore and particle size; the templates are subsequently removed by calcinations. The present study is focused to employ a novel, simple, one spot synthesis of poly aminoalkyl siloxane, an organic inorganic hybrid, by the hydrolysis and condensation of triethoxy aminopropyl silane that can entrap 5-fluorouracil (5-FU), a model drug. The synthesized material was characterized by FT-IR spectroscopy. The data strengthening that it can be a convenient substitute for hitherto reported several mesoporous materials to take-in and release slowly of any potentially toxic drugs to treat colo-rectal cancer like diseases.