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Observing patterns in MRI with QSM in Patients with SOD1 and C9ORF72 Genetic ALS
Introduction: The most common forms of familial ALS are due to the C9ORF72 and SOD1 genes. Pathology studies have demonstrated patients with C9ORF72 ALS tend to develop more protein aggregates in the cerebellum and temporal lobes, while SOD1 patients develop more protein aggregates in the frontal and temporal lobes. (REF). Other means of looking for these signs are not established. Currently, we use brain MRI quantitative susceptibility mapping analysis (QSM) to examine susceptibility in thedoi:10.21203/rs.3.rs-83304/v1 fatcat:lr3senx5ajf7zew3xkj23lytva