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Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies
Infantile onset hereditary spastic paralysis (IAHSP) is a rare neurological disease diagnosed in less than 50 children worldwide. It is transmitted with a recessive pattern and originates from mutations of the ALS2 gene, encoding for the protein alsin and involved in differentiation and maintenance of the upper motoneuron. The exact pathogenic mechanisms of IAHSP and other neurodevelopmental diseases are still largely unknown. However, previous studies revealed that, in the cytosolicdoi:10.3390/molecules27207063 fatcat:nbf6lvcgvzanzptlzz4flxr6oq