Navigating the ClpB channel to solution

James Shorter, Susan Lindquist
2005 Nature Structural & Molecular Biology  
New work places the Hsp70/DnaK system in an opening role in protein disaggregation, facilitating the extraction of individual polypeptides from the aggregate surface to the axial channel of Hsp104/ClpB. It also reinforces a longstanding belief that reactivation rather than simple clearance of aggregated protein is necessary for cell stress tolerance.
doi:10.1038/nsmb0105-4 pmid:15689967 fatcat:y7cqx2zkuvarhij47frrraloxq