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New work places the Hsp70/DnaK system in an opening role in protein disaggregation, facilitating the extraction of individual polypeptides from the aggregate surface to the axial channel of Hsp104/ClpB. It also reinforces a longstanding belief that reactivation rather than simple clearance of aggregated protein is necessary for cell stress tolerance.doi:10.1038/nsmb0105-4 pmid:15689967 fatcat:y7cqx2zkuvarhij47frrraloxq