Flexibility of nucleic acids: from DNA to RNA [article]

Lei Bao, Xi Zhang, Lei Jin, Zhi-Jie Tan
2015 arXiv   pre-print
The structural flexibility of nucleic acids plays a key role in many fundamental life processes, such as gene replication and expression, DNA-protein recognition, and gene regulation. To obtain a thorough understanding of nucleic acid flexibility, extensive studies have been performed using various experimental methods and theoretical models. In this review, we will introduce the progress that has been made in understanding the flexibility of nucleic acids including DNAs and RNAs, and will
more » ... size the experimental findings and the effects of salt, temperature, and sequence. Finally, we will discuss the major unanswered questions in understanding the flexibility of nucleic acids.
arXiv:1509.06450v2 fatcat:5snrf6sovnemrny2gixtptdoyy