Spatial regulation of dual flagellar systems

Florian Roßmann, Thormann, Kai (Prof. Dr.)
<span title="2017-08-28">2017</span>
Many cellular processes are highly spatially ordered, with spatial separation regulated by cellular factors called landmark proteins. Examples of compartmentalized processes are those involved in bacterial motility. In bacteria, swimming and swarming require the formation of flagella - long, rotating, helical filaments driven by a membrane-embedded motor. Landmark proteins likely regulate the numerous flagellation patterns found in a variety of bacterial species. In polarly flagellated
more &raquo; ... primarily encountered in marine habitats, the SRP-like GTPase FlhF and the MinD-like ATPase FlhG are known to control flagellar positioning and number. HubP, another polar factor identified in Vibrio cholerae, was shown to be involved in the localization of proteins which are a part of other cellular processes such as chemotaxis, enabling the cell to navigate efficiently towards more favorable conditions. The polarly flagellated gammaproteobacterium Shewanella putrefaciens CN-32 possesses two flagellar systems encoded in two gene clusters, enabling the cell to form a single polar and multiple lateral flagella. However, genes for only a single chemotaxis system are located on the chromosome. The primary polar system is required for the main propulsion of the cell. Since only the motor switch protein of the polar system, FliM1, harbors the binding domain of the chemotaxis response regulator CheY, the chemotaxis system also acts exclusively on this flagellar motor. Secondary, lateral flagella enable the cell to turn more efficiently by biasing the directional changes of the swimming cell towards smaller turn angles. This leads to a higher directional persistence in the swimming path of the cell. Since the positions of both the polar and lateral flagella play key roles in this special movement pattern, the mode of action of the regulator [...]
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.17192/z2017.0061</a> <a target="_blank" rel="external noopener" href="">fatcat:huqcnpml3jgmzmqc3i5zks4v7q</a> </span>
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