The contrast of the interface between the neocortical grey matter and the white matter is emerging as an important neuroimaging phenotype for several brain disorders. To date, a single in vivo study has analysed the cortical grey-to-white matter percent contrast (GWPC) on Magnetic Resonance Imaging (MRI), and has shown a significant decrease of this contrast in several areas in individuals with Autism Spectrum Disorder (ASD). Our goal was to replicate this study across a larger cohort, using

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... multicenter data from the Autism Brain Imaging Data Exchange 1 and 2 gathering data from 2,148 subjects. Multiple linear regression was used to study the effect of the diagnosis of ASD on the GWPC. Contrary to the first study, we found a statistically significant increase of GWPC among individuals with ASD in left auditory and bilateral visual sensory areas, as well as in the left primary motor cortex. These results were still statistically significant after inclusion of cortical thickness as covariate. There are numerous reports of sensory-motor atypicalities in patients with ASD, which may be the reason for the differences in GWPC that we observed. Further investigation could help us determine the potential role of a defect or a delay in intra-cortical myelination of sensory-motor regions in ASD. Code: https://github.com/neuroanatomy/GWPC​.