The assessment of carotid intima-media thickness, lipid profiles and oxidative stress markers in Helicobacter pylori-positive subjects

Sebahat BASYIGIT, Halide AKBAS, Inci SULEYMANLAR, Didem KEMALOGLU, Serkan KOÇ, Gultekin SULEYMANLAR
2012 The Turkish Journal of Gastroenterology  
Girifl ve Amaç: Helikobakter pilori infeksiyonunun ateroskleroz ile iliflkili oldu¤u ileri sürülmüfltür. Bu konu halen çeliflkilidir. Anormal lipid profili ve oksidatif stresin ateroskleroz ve karotis intima media kal›nl›¤› ile iliflkili oldu¤u iyi bilinmektedir. Bu çal›fl-man›n amac› Helikobakter pilori pozitif ve negatif bireylerde karotis intima media kal›nl›¤› ve oksidatif stresin belirteçlerini lipid parametreleri do¤rultusunda araflt›rmakt›r. Gereç ve Yöntem: Çal›flmaya 30 Helikobakter
more » ... ori pozitif birey ve 31 Helikobakter pilori negatif birey kat›ld›. Helikobakter pilori infeksiyonu noninvaziv testlerle teflhis edildi. Serum total oksidatif status ve total antioksidatif kapasite düzeyleri ölçüldü. Oksidatif stres indeksi total oksidatif status/antioksidatif kapasite oran›na dayanarak hesap-land›. Geleneksel kardiyovasküler risk faktörleri kaydedildi ve serum trigliserit, yüksek yo¤unluklu lipoprotein kolesterol ve düflük yo¤unluklu lipoprotein kolesterol dahil laboratuvar analizleri çal›fl›ld›. Yüksek çözünürlüklü ultrason ile karotis intima media ka-l›nl›¤› ölçüldü. Bulgular: Helikobakter pilori pozitif bireylerde ortalama ve maksimum sa¤ ve genel karotis intima media kal›nl›¤› de¤erlerini Helikobakter pilori negatiflere göre anlaml› olarak daha kal›n bulduk (p<0.05). Helikobakter pilori pozitif bireylerin serum trigliserit seviyeleri Helikobakter pilori negatiflerden anlaml› olarak daha yüksekti (p<0.05). Total oksidatif status, total antioksidatif kapasite, oksidatif stres indeksi de¤erleri Helikobakter pilori pozitif bireylerde negatiflere k›yasla anlaml› olarak daha yüksekti (p<0.05). Oksidatif stresin belirteçleri ve karotis intima media kal›nl›¤› de¤erleri aras›nda anlaml› korelasyon gözlenmedi. Sonuç: Helikobakter pilori pozitif bireylerde negatiflere k›yasla karotis intima media kal›nl›¤›, total oksidatif status, total antioksidatif kapasite, oksidatif stres indeksi ve trigliserit de¤erlerinde anlaml› yükselme vard›r. Bu bilgiler Helikobakter pilori infeksiyonunun ateroskleroz mekanizmas›nda bir rolü olabilece¤ini iflaret eder. Anahtar kelimeler: Helikobakter infeksiyonlar›, ateroskleroz, oksidatif stres, hipertrigliseridemi Background/aims: Helicobacter pylori infection has been suggested to be associated with atherosclerosis. The issue is still controversial. It is well known that abnormal lipid profile and oxidative stress are related to atherosclerosis and the measurement of carotid intima-media thickness. The aim of this study was to investigate carotid intima-media thickness and oxidative stress along with lipid parameters in Helicobacter pylori-positive and -negative subjects. Materials and Methods: Thirty Helicobacter pylori-positive subjects and 31 Helicobacter pylori-negative subjects were enrolled. Helicobacter pylori infection was diagnosed by noninvasive tests. Serum total oxidant status and total antioxidant capacity levels were measured. Oxidative stress index was calculated based on total oxidant status/total antioxidant capacity ratio. Traditional cardiovascular risk factors were recorded, and laboratory analysis included measurement of serum triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol. carotid intimamedia thickness was assessed by high-resolution ultrasound. Results: We found that the mean and maximum values of right and overall carotid intima-media thickness in Helicobacter pylori-positive subjects were significantly thicker than in Helicobacter pylori-negatives (p<0.05). Serum triglycerides levels of Helicobacter pylori-positive subjects were significantly higher than in Helicobacter pylori-negatives (p<0.05). Total oxidant status, total antioxidant capacity and oxidative stress index values were significantly higher in Helicobacter pylori-positive subjects compared with negatives (p<0.05). No significant correlation was observed between oxidative stress markers and carotid intima-media thickness values. Conclusions: Carotid intima-media thickness, total oxidant status, total antioxidant capacity, oxidative stress index, and triglycerides values are increased in Helicobacter pylori-positive subjects compared to Helicobacter pylori-negatives. These data indicated that Helicobacter pylori infection may have a role in atherosclerotic processes.
doi:10.4318/tjg.2012.0441 fatcat:f4kj6zrcvjdl3bzluydzyltzf4