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Central nervous system infections are amongst the most severe, yet the mechanisms by which pathogens access the brain remain poorly understood. The model microorganism Listeria monocytogenes (Lm) is a major foodborne pathogen that causes neurolisteriosis, one of the deadliest central nervous system infections. While immunosuppression is a well-established host risk factor for neurolisteriosis, little is known regarding the bacterial factors underlying Lm neuroinvasion. We have developed adoi:10.1101/2020.11.20.384974 fatcat:rf2znq36jjellbbh7gst54cdmq