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MTSS1 is a metastasis driver in a subset of human melanomas
In cancers with a highly altered genome, distinct genetic alterations drive subsets rather than the majority of individual tumours. Here we use a sequential search across human tumour samples for transcript outlier data points with associated gene copy number variations that correlate with patient's survival to identify genes with pro-invasive functionality. Employing loss and gain of function approaches in vitro and in vivo, we show that one such gene, MTSS1, promotes the ability ofdoi:10.1038/ncomms4465 pmid:24632752 fatcat:kmmpgr7445fhhgnv2nss25klba