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COVID-19, cytokine storm and sigma-1 receptors: potential treatments at hand?
Fluvoxamine, a usual SSRI antidepressant, has agonistic activity on Sigma-1 receptors in ER and inhibits IRE1, an important trigger of cytokine production; Sigma-1 receptor is a target of SARS-COV-2 protein Nsp6 and may start the cytokine storm.doi:10.22541/au.159335613.31156244/v2 fatcat:6l3yd3s3xjgippo7rnko4o2jbq