NAViGaTing the Micronome – Using Multiple MicroRNA Prediction Databases to Identify Signalling Pathway-Associated MicroRNAs

Elize A. Shirdel, Wing Xie, Tak W. Mak, Igor Jurisica, Esteban Ballestar
2011 PLoS ONE  
MicroRNAs are a class of small RNAs known to regulate gene expression at the transcript level, the protein level, or both. Since microRNA binding is sequence-based but possibly structure-specific, work in this area has resulted in multiple databases storing predicted microRNA:target relationships computed using diverse algorithms. We integrate prediction databases, compare predictions to in vitro data, and use cross-database predictions to model the microRNA:transcript interactome -referred to
more » ... s the micronome -to study microRNA involvement in well-known signalling pathways as well as associations with disease. We make this data freely available with a flexible user interface as our microRNA Data Integration Portal -mirDIP (http://ophid.utoronto.ca/mirDIP).
doi:10.1371/journal.pone.0017429 pmid:21364759 pmcid:PMC3045450 fatcat:riqohyacfrhfrgljrwivjfkiia