Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery

Ýrr Mørch, Rune Hansen, Sigrid Berg, Andreas K. O. Åslund, Wilhelm R. Glomm, Siv Eggen, Ruth Schmid, Heidi Johnsen, Stephan Kubowicz, Sofie Snipstad, Einar Sulheim, Sjoerd Hak (+5 others)
2015 Contrast Media & Molecular Imaging  
Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology platform incorporating multiple functionalities, including imaging and therapy in a single system consisting of MBs stabilized by polyethylene glycol (PEG) coated polymeric nanoparticles (NPs). The NPs, containing lipophilic drugs and/or contrast agents, are composed of the
more » ... widely used poly(butyl cyanoacrylate) (PBCA) polymer and prepared in a single step. MBs stabilized by these NPs are subsequently prepared by self-assembly of NPs at the MB air/liquid interface. Here we show that these MBs can act as contrast agents for conventional ultrasound imaging. Successful encapsulation of iron oxide NPs inside the PBCA NPs is demonstrated, potentially enabling the NPs/MBs to be used as magnetic resonance imaging (MRI) and/or molecular ultrasound imaging contrast agents. By precise tuning of the applied ultrasound pulse, the MBs burst and the NPs constituting the shell are released. This could result in increased local deposit of NPs into target tissue providing improved therapy and imaging contrast compared to freely distributed NPs.
doi:10.1002/cmmi.1639 pmid:25930237 fatcat:dgem65hojveyliaqqtr5xuardi