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Although protein C was described as an anticoagulant in 1960 by Dr. Seegers and colleagues, 1 widespread appreciation of the complexity of its activation, function, and physiological roles did not begin to develop until Stenflo independently characterized protein C as a vitamin K-dependent zymogen 2 that could be converted to a serine protease capable of membrane binding (Esmon et al 3 ). The subsequent demonstrations by Kisiel et al 4 that activated protein C was an anticoagulant thatdoi:10.1161/01.atv.12.2.135 fatcat:hhpz23lsgrauvmg3zxc7jmxmmm