THE first p a r t of this investigation (Carr and Pyman, P., 1913, 29, 226; T., 1914, 105, 1591) characterised the then known alkaloids of ipecacuanha-emetine, cepliaeline, and psychotrineand explained their mutual relations. Psychotrine was shown to have the formula C18HS604N2, and to yield on reduction a mixture of ce'phaeline and isocephaeline, both of which had t h e formula C"H"O,N,. Emetine proved to be the inonomethyl ether of cephaeliim, and had the formula C29H"0,N2. Several

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... derivatives of these alkaloids were described, and it was also shown that emetiiie gave on oxidation 6 : 7-dimethoxyisoquinoline-lcarboxylic acid, whence i t followed t h a t these three alkaloids belong to the large class of naturally occurring bases derived from isoquinoline. * * After the above paper had been written, but before its publication in the Transactions, 0. Hesse (Annulen, 1914,405, 1) recorded the results of an investigation on the same subject, and these were briefly discussed in an addendum to the first part of this research (Zoc. cit., p. 1637). Hesse confirmed the formula C"H"O,N, which he had previously (Pharm. J . , 1898, R* 2