Echo planar imaging (EPI) is the most common method of functional magnetic resonance imaging for acquiring the blood oxygenation level-dependent (BOLD) contrast. One of the primary benefits of using EPI is that an entire volume of the brain can be acquired on the order of two seconds. However, this speed benefit comes with a cost. Because imaging protocols are limited by hardware (e.g., fast gradient switching), researchers are forced to compromise between spatial resolution, temporal

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... , or whole-brain coverage. Earlier attempts to circumvent this problem included developing protocols in which slices of a volume were acquired faster (i.e., slice (S) acceleration), while more recent protocols allow for multiple slices to be acquired simultaneously (i.e., multiband (MB) acceleration). However, applying such acceleration methods can lead to a reduction in the temporal signal-to-noise ratio (tSNR), which is a critical measure of the stability of the signal over time. Here we show, in five healthy subjects, using a 20- and 64-channel receiver coil, that enabling S-acceleration consistently yielded, as expected, a substantial decrease in tSNR, regardless of the receiver coil employed, whereas tSNR decrease resulting from MB acceleration was less pronounced. Specifically, with the 20-channel coil, tSNR of upto 4-fold MB-acceleration is comparable to that of no acceleration, while up to 6-fold MB-acceleration with the 64-channel coil yields comparable tSNR to that of no acceleration. Moreover, observed tSNR losses tended to be localized to temporal, insular, and medial brain regions and were more noticeable in the 20- than in the 64-channel coil. Conversely, with the 64-channel coil, the tSNR in lateral frontoparietal regions remained relatively stable with increasing MB factors. Such methodological explorations can inform researchers and clinicians as to how they can optimize imaging protocols depending on the available hardware and the brain regions they want to investigate.