DISTURBANCE OF OESTROUS CYCLES IN RATS FOLLOWING ADMINISTRATION OF FREUND'S COMPLETE ADJUVANT

J. R. BATTISTO, M. PINTO, S. JOSEPH
1967 Reproduction  
Female rats injected with Freund's complete adjuvant in the hind limb footpads had abnormal oestrous cycles characterized by prolonged leucocytic phases. This was observed within 2 days in some animals given adjuvant on the first day of di-oestrus. About one-fourth of the animals with abnormal cycles had the same number of continuous L-days as animals made pseudopregnant by electrical stimulation (11 to 16 days). Although electrical stimulation of the cervix induced pseudopregnancy optimally
more » ... n applied at pro-oestrus, adjuvant induced pseudopregnancy equally well whether injected at pro-oestrus or dioestrus.
doi:10.1530/jrf.0.0140147 pmid:6068583 fatcat:bkib4jeisffizb4fdo36x23ksa