Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning

C. Lam, M. A. S. Vergnolle, L. Thorpe, P. G. Woodman, V. J. Allan
2010 Journal of Cell Science  
Cytoplasmic dynein 1 is a minus-end-directed microtubule motor that is required for a wide range of activities involving movement or anchoring of cellular structures (Vallee et al., 2004) . These activities include separation of chromosomes during mitosis, cell migration, and the movement and localisation of substrates such as mRNAs, signalling complexes and membrane organelles. To understand how dynein function over such a diverse range of activities is regulated, much attention has focussed
more » ... the composition of the dynein motor complex and the roles of accessory proteins.
doi:10.1242/jcs.059337 pmid:20048338 fatcat:xsemj6dpd5ajhediao3nigkpum