A STUDY OF COMPARATIVE ASSESSMENT OF THE EFFICACY & SAFETY OF SERTACONAZOLE 2% CREAM VERSUS TERBINAFINE 1% CREAM IN PATIENTS WITH DERMATOPHYTOSES OF SKIN
Journal of Evidence Based Medicine and Healthcare
BACKGROUND: Sertaconazole, a new broad spectrum fungicidal and fungistatic imidazole antifungal drug is having an added good antipruritic and anti-inflammatory action. This beneficial action of Sertaconazole provides much symptomatic relief to the patients with dermatophytic infections of the skin and thereby it improves the quality of life in these patients. AIMS AND OBJECTIVES: To make comparative assessment of the efficacy and safety of Sertaconazole 2% cream and Terbinafine 1% cream in
... nts with dermatophytoses of skin. MATERIALS AND METHODS: 40 patients with dermatophytic infections like tinea corporis, tinea cruris and tinea faciei attending the skin OPD, Government General Hospital, Anantapur were enrolled in this prospective, single blind, randomized study. Patients were randomized into two groups A & B with 20 patients in each group. In the initial 'Treatment Phase', group A patients received the sertaconazole nitrate 2% cream applied topically twice daily for four weeks and group B patients received the Terbinafine hydrochloride 1% cream applied topically twice daily for two weeks. In the 'Follow-up Phase' i.e. 2 weeks after the completion of treatment phase, all the patients in this study were assessed clinically and mycologically for the relapse of dermatophytic infections. RESULTS: Out of the total 40 patients in this study, 97% of Sertaconazole group patients and 91% of Terbinafine group patients showed significant improvement in their signs and symptoms (pruritus, erythema, papules, vesicles, scaling and mycological cure) as compared to their baseline in the treatment phase and in the follow-up phase it was 100% in Sertaconazole group and 95% in terbinafine group. Higher number of patients showed decrease of pruritus in the Sertaconazole group (90%) as compared to the Terbinafine group (50%) (p < 0.05 Sertaconazole vs Terbinafine). Both the drugs were well tolerated and did not show recurrences by the mycological assessment. CONCLUSION: Sertaconazole was better than terbinafine in relieving the signs and symtoms of dermatophytic infections and there is no recurrence of dermatophytic infections in all the patients who used these drugs at the end of follow up phase as per the mycological assessment.