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Adipose-derived cellular therapies prolong graft survival in an allogenic hind limb transplantation model
Stem Cell Research & Therapy
Background The long-term survival after vascularized composite allotransplantation (VCA) is often limited by systemic rejection as well as the adverse effects of immunosuppressants. The stromal vascular fraction (SVF) can be expanded to produce adipose-derived stem cells (ADSC) which represents a combination of endothelial cells, preadipocytes, immune cells, and ADSC. It has been demonstrated that ADSC possess consistently reliable clinical results. However, literature is scarce regarding SVFdoi:10.1186/s13287-021-02162-7 pmid:33514430 fatcat:zhxtkbfi6nh33d6attp2bu2pfa