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Retinoic Acid Inhibits in vitro Development of Mast Cells But Has No Marked Effect on Mature Human Skin Tryptase- and Chymase-Positive Mast Cells
Journal of Investigative Dermatology
Stem cell factor plays a key role in the development of human mast cells via interaction with Kit receptor. We and other groups have previously shown that a number of cytokines can regulate the stem-cell-factor-dependent development of mast cells in vitro. In this study we investigated the e¡ect of retinoic acid on human mast cells in vitro and in vivo. Retinoids are known to have strong modulatory e¡ects on hematopoietic di¡erentiation. We found that all-trans-retinoic acid, at concentrationsdoi:10.1046/j.1523-1747.2003.12030.x pmid:12542529 fatcat:txaaf5g4cfbi7cifz4frrfyg4u