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Vitamin D deficiency is thought to be common in Australia. It is unclear when vitamin D supplementation should be prescribed. We assess the evidence that guides clinical decision-making on supplementation with vitamin D following a vitamin D test result. Vitamin D assays are inconsistent and inaccurate and there is weak evidence around the level of 25-hydroxyvitamin D (25(OH)D) that is optimal. Evidence of links between vitamin D deficiency and disease come from observational studies and therepmid:24600673 fatcat:527urupryrd2pjls7sot2eydgu