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Mass spectrometry-based profiling of the carbon starved Escherichia coli proteome reveals upregulation of stress-inducible pathways implicated in biofilm formation and antibiotic resistance
Starvation is a complex adaptive response to insufficiency of nutrients that has been known to implicate a number of stress networks, and modulate pathogenicity and antibiotic resistance in bacteria. However, naturally occurring abrupt elimination of nutrients and prolonged periods of their complete absence, e.g. when bacteria are placed in natural or artificial water reservoirs, are qualitatively different from in-culture late stationary phase energy source diminution. Despite the obviousdoi:10.7287/peerj.preprints.1572v1 fatcat:7kwcbmj63ve25ejcy43kygbmuu