Functional differentiation of medial temporal and frontal regions involved in processing novel and familiar words: an fMRI study

Andrew J. Saykin, Sterling C. Johnson, Laura A. Flashman, Thomas W. McAllister, Molly Sparling, Terrance M. Darcey, Chad H. Moritz, Stephen J. Guerin, John Weaver, Alexander Mamourian
1999 Brain  
Results of recent functional magnetic resonance imaging (fMRI) studies of memory are not entirely consistent with lesion studies. Furthermore, although imaging probes have identified neural systems associated with processing novel visual episodic information, auditory verbal memory using a novel/familiar paradigm has not yet been examined. To address this gap, fMRI was used to compare the haemodynamic response when listening to recently learned and novel words. Sixteen healthy adults (6 male,
more » ... female) learned a 10-item word list to 100% criterion, 1 h before functional scanning. During echo-planar imaging, subjects passively listened to a string of words presented at 6-s intervals. Previously learned words were interspersed pseudo-randomly between novel words. Mean scans corresponding to each word type were analysed with a random-effects model using statistical parametric mapping (SPM96). Familiar (learned) words activated the right prefrontal cortex, posterior left parahippocampal gyrus, left medial parietal cortex and Keywords: fMRI, episodic memory, hippocampus Abbreviations: BOLD ϭ blood oxygen level-dependent; fMRI ϭ functional magnetic resonance imaging; HRF ϭ haemodynamic response function; MTL ϭ medial temporal lobe; SPM ϭ statistical parametric mapping
doi:10.1093/brain/122.10.1963 pmid:10506097 fatcat:ho3igmkrsbb2tbmqt3kilw2xru