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VAPPER: High-throughput variant antigen profiling in African trypanosomes of livestock
2019
GigaScience
Background Analysing variant antigen gene families on a population scale is a difficult challenge for conventional methods of read mapping and variant calling due to the great variability in sequence, copy number, and genomic loci. In African trypanosomes, hemoparasites of humans and animals, this is complicated by variant antigen repertoires containing hundreds of genes subject to various degrees of sequence recombination. Findings We introduce Variant Antigen Profiler (VAPPER), a tool that
doi:10.1093/gigascience/giz091
pmid:31494667
pmcid:PMC6735694
fatcat:wq4cafycy5hdxj5ayurtuxvnhm