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Traditional imaging modalities such as computed tomography, although perfectly adept at identifying and quantifying advanced calcification, cannot detect the early stages of this disorder and offer limited insight into the mechanisms of mineral dysregulation. This review presents optical molecular imaging as a promising tool that simultaneously detects pathobiological processes associated with inflammation and early stages of calcification in vivo at the (sub)cellular levels. Research intodoi:10.1161/circresaha.110.234146 pmid:21617135 pmcid:PMC3139950 fatcat:rntismtmgffnpc25dtk2t7ywkm