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The endogenous cannabinoid system has been shown recently to play a crucial role in the extinction of aversive memories. In Cannabis sativa was found more than sixty one substance that cannabinoid was named. The aim of this study is the effect of leaves aqueous and alcoholic extracts of Cannabis sativa on CA2 neuronal density of hippocampus in male rats. Forty male Wistar Rats weight (300-350 g) were completely divided into four experimental groups and one control group. Cannabis sativa wasfatcat:45iydeqp5fbuzec5qf7tczxuti