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Insulin increases branched-chain α-ketoacid dehydrogenase kinase expression in Clone 9 rat cells
American Journal of Physiology. Endocrinology and Metabolism
Nellis, Mary M., Christopher B. Doering, Andrea Kasinski, and Dean J. Danner. Insulin increases branchedchain ␣-ketoacid dehydrogenase kinase expression in Clone 9 rat cells. The branched-chain amino acids (BCAA) are committed to catabolism by the activity of the branched-chain ␣-ketoacid dehydrogenase (BCKD) complex. BCKD activity is regulated through the action of the complex-specific BCKD kinase that phosphorylates two serine residues in the E1␣ subunit. Greater BCKD kinase expression levelsdoi:10.1152/ajpendo.00133.2002 pmid:12217904 fatcat:6x3uj2rasjdo5csapa4xao3rki