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Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study

Elżbieta Kalicińska, Monika Biernat, Justyna Rybka, Aleksander Zińczuk, Justyna Janocha-Litwin, Marta Rosiek-Biegus, Marta Morawska, Anna Waszczuk-Gajda, Joanna Drozd-Sokołowska, Łukasz Szukalski, Marcin Rymko, Paula Jabłonowska (+2 others)
2021 Journal of Clinical Medicine  

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COVID-19, as a disease involving the endothelium of multiple organs, is characterized by high mortality rates among hospitalized patients. Patients with hematological malignancies are particularly at risk of an unfavorable course of COVID-19. The endothelial activation and stress index (EASIX) score has been used as a simple predictor of overall survival (OS) in specific groups of hematological cancer patients. EASIX, as a biomarker of endothelial dysfunction, might play a prognostic role in
more » ... ients with COVID-19. Here, we performed a comprehensive retrospective analysis of the EASIX score in 523 hospitalized COVID-19 patients with or without coexisting hematological cancer. Hematological cancer COVID-19 patients had higher EASIX scores compared to the overall population with COVID-19. In hematological patients, EASIX was a strong predictor of the occurrence of sepsis during COVID-19. Our findings demonstrated EASIX as a strong predictor of intensive care unit admission, in-hospital mortality, the occurrence of acute renal failure and the need for hemodialysis, both in hematological and non-hematological COVID-19 patients. Patients with a high EASIX score on COVID-19 diagnosis had significantly inferior OS compared to patients with low EASIX. We showed for the first time that EASIX might serve as a simple, universal prognostic tool of OS in both hematological and non-hematological COVID-19 patients.
doi:10.3390/jcm10194373 pmid:34640390 fatcat:rccr32qeqfaqpfatfvq3mvekwy
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Elżbieta Kalicińska, Monika Biernat, Justyna Rybka, Aleksander Zińczuk, Justyna Janocha-Litwin, Marta Rosiek-Biegus, Marta Morawska, Anna Waszczuk-Gajda, Joanna Drozd-Sokołowska, Łukasz Szukalski, Marcin Rymko, Paula Jabłonowska, Krzysztof Simon, Tomasz Wróbel. "Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study." Journal of Clinical Medicine 10.19 (2021) 4373