Internet Archive Scholar

EFFICIENCY OF BONE MARROW PRECURSOR CELL COLONY-FORMING AS A PREDICTOR OF DISEASE COURSE IN PLASMA CELL MYELOMA PATIENTS WITH A HISTORY OF RADIATION EXPOSURE
EFEKTYVNIST' KOLONIIeUTVORENNIa KLITYN-POPEREDNYKIV KISTKOVOGO MOZKU, IaK PROGNOSTYChNYĬ FAKTOR PEREBIGU PLAZMOKLITYNNOÏ MIIeLOMY U OSIB Z RADIATsIĬNYM ANAMNEZOM

Zh. Minchenko, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine, T. Liubarets, V. Balan, O. Dmytrenko, T. Shlyakhtichenko, V. Moyseyenko, Yu. Silayev, V. Bebeshko, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine (+5 others)
2020 Problemi radìacìjnoï medicini ta radìobìologìï  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (1.8 MB)
https://web.archive.org/web/20220117042058/http://radiationproblems.org.ua/25_2020/NCRM_2020_Paper_30.pdf

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL. The file type is application/pdf.

Objective. Assessment of role of the bone marrow colony-forming efficiency in plasma cell myeloma patients at different stages of treatment as a prognostic criterion for the disease course. Materials and methods. The colony forming efficiency (CFE) was assayed in stage I–II plasma cell myeloma (PCM) patients (n = 37) aged 42–73, namely in patients survived after the Chornobyl NPP accident (n = 21) and persons not exposed to ionizing radiation (n = 16). There were 11 males exposed to ionizing
more » ... iation and having got stage I PCM, 9 males and 3 females exposed and having got stage II PCM, 3 males and 3 females not exposed and having got stage I PCM, 6 males and 2 females not exposed and having got stage II PCM. Healthy persons (n = 20) were included in the control group. Results. Number of the bone marrow (BM) granulocyte-macrophage colony-forming units (CFU-GM) in both exposed and not exposed PCM patients depended on a disease stage. CFU-GM was (16.7 ± 1.2) in the stage I PCM patients vs. (11.1 ± 1.1) in the stage II PCM ones both being lower (p < 0.05) compared to control (64.5 ± 2.2). Changes in cluster formation were similar, i.e. (37.7 ± 1.6) and (19.4 ± 1.3) correspondingly in the stage I and stage II PCM patients. Respective values in control were (89.8 ± 3.6). The CFE in stage I and stage II PCM patients at the time of diagnosis was lower (5.7 ± 1.5 and 2.4 ± 1.1 respectively) vs. control (39.5 ± 1.51, p < 0.05), but has increased in remission up to (29. 6 ± 1.8) and (13.8 ± 1.2) respectively. There was no difference at that between the irradiated and non-irradiated patients. Number of the fibroblast colony-forming units (CFU-F) in the stage I and stage II PCM patients during diagnosis, namely (43.9 ± 5.4) and (22.5 ± 3.7), was lower (p < 0.05) vs. control (110.5 ± 4.9). Upon reaching remission the CFU-F value increased significantly (p < 0.05), reaching (87.4 ± 4.2) and (55.6 ± 2.7) correspondingly in the stage I and stage II PCM patients. Conclusion. Dependence of the BM cell CFE on the stage of PCM and presence or absence of remission was established. Prognostic value of the CFE of BM CFU-GM in terms of life span of patients was shown (Ro Spearm = 0.39, p < 0.02), namely in case of CFE > 20 before the polychemotherapy administration the life span of PCM patients was significantly longer vs. cases of CFE < 20. Key words: plasma cell myeloma, bone marrow, granulocyte-macrophage colony-forming unit, fibroblast colony-forming unit, cluster.
doi:10.33145/2304-8336-2020-25-490-501 pmid:33361856 fatcat:tqeypsj3z5cszofuydfjc5lfxu
Open Access
Citation

Zh. Minchenko, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine, T. Liubarets, V. Balan, O. Dmytrenko, T. Shlyakhtichenko, V. Moyseyenko, Yu. Silayev, V. Bebeshko, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine, Bogomolets National Medical University of the Ministry of Health of Ukraine, 13 Tarasa Shevchenka Blvd., Kyiv, 01601, Ukraine, Private Higher Educational Institution «International Academy of Ecology and Medicine», 121 Kharkivske Hwy., Kyiv, 02000, Ukraine, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine, State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine. "EFFICIENCY OF BONE MARROW PRECURSOR CELL COLONY-FORMING AS A PREDICTOR OF DISEASE COURSE IN PLASMA CELL MYELOMA PATIENTS WITH A HISTORY OF RADIATION EXPOSURE." Problemi radìacìjnoï medicini ta radìobìologìï (2020) 490-501