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Efforts to identify the genetic underpinnings of rare undiagnosed diseases increasingly involve the use of next-generation sequencing and comparative genomic hybridization methods. These efforts are limited by a lack of knowledge regarding gene function, and an inability to predict the impact of genetic variation on the encoded protein function. Diagnostic challenges posed by undiagnosed diseases have solutions in model organism research, which provides a wealth of detailed biologicaldoi:10.1534/genetics.117.203067 pmid:28874452 pmcid:PMC5586389 fatcat:bhaf43bq45dcnnjuoklczpm5ui