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Aims: To examine molecular and metabolic consequences of HPV-16 viral-protein E6, which targets p53 for degradation, in A2780 (ovarian cancer) cells. Methods: Isogenic derivatives of A2780 cells, with empty-vector (E6-) or E6 (E6+) transfection, were cultured. Intracellular metabolites, fatty acids, and the flux of glutamine, glucose, alanine and lactate in proliferation (Day 2) and confluence (Day 4) were determined using MRS. Western blotting confirmed p53 status, protein expressions relateddoi:10.1159/000356583 pmid:24296520 fatcat:a3p722jhxnftlchi5tzkbveiqy