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Mirtazapine is a tetracyclic anti-depressant drug approved by USFDA to treat depression. It is a BCS class II drug with a low oral bioavailability of 50% due to first pass metabolism. Thus, the purpose of this research work was to enhance the bioavailability of the drug by enhancing its solubility by incorporating it in to niosomal vesicles loaded in to an in-situ gel to enhance its permeability across the biological membrane. Niosomes were prepared by thin film hydration method and optimizeddoi:10.5281/zenodo.3243299 fatcat:nipt4lz3drcmnphican4xsfpay