Vaccine immunology

Oberdan Leo, Anthony Cunningham, Peter L. Stern
2011 Perspectives in Vaccinology  
Key concepts n The human immune system consists of two connected compartments e the innate and adaptive e which function via the actions of secreted and cellular effectors n The innate and adaptive immune systems work sequentially to identify invaders and formulate the most appropriate response; this interaction is crucially bridged by specialised antigen-presenting cells (APCs) n The innate response, via the action of APCs, sets the scene for the subsequent adaptive response by providing
more » ... ation about the nature of the threat n Primary exposure to a pathogen or antigen induces the production of a population of adaptive immune cells with antigen specificity that are retained for long periods and provide a rapid response upon subsequent exposure n The vaccine concept is based on stimulating the body's defence mechanisms against a specific pathogen to establish this immunological memory n Current vaccine strategies take advantage of immunological mechanisms, and often target the innate immune system and APCs to induce the desired specific adaptive immune response n Future research is also set to examine ways of making the immune response more effective in generating cross protective responses against different subtypes or strains of pathogens exhibiting antigenic variation Ó 2011 Elsevier B.V.
doi:10.1016/j.pervac.2011.05.002 fatcat:u7wmozd4ffai7b4rem7oh75mky