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Background: Neonatal lupus erythematosus (NLE) is an uncommon immunemediated disease caused by the transplacental passage of maternal autoantibodies. In this paper, we described a case of a newborn with NLE involving lung damage from clinical diagnoses to autopsy findings. Case presentation: The mother had no history of immune system disease; however, the test for antinuclear antibodies was positive. A boy was delivered spontaneously at 36+2 weeks' gestation without asphyxia (birth weight: 1.21doi:10.21203/rs.3.rs-951370/v1 fatcat:7ym42o44frguxgirm4fnlgszdi