Sulfonamides are a class of compounds with a wide range of biological activities. The synthesis of a novel sulfapyrimidine derivative is reported in this article. The approach to the synthesis of the compound is based on reacting N-(6-Chloro-5-cyano-4-p-tolylpyrimidin-2-yl) benzenesulfonamide and morpholine to afford N-[5-cyano-4-(morpholin-4-yl)-6-phenylpyrimidin-2-yl]benzenesulfonamide. The title compound incorporates three pharmacophores, namely the (i) pyrimidine, (ii) morpholine, and (iii)

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... benzenesulfonamide moieties. Each of these groups possesses a characteristic set of chemical reactivity and biological activities. The newly synthesized compound is anticipated to possess significantly enhanced pharmacological features. The structure of the compound was confirmed by spectroscopic and single crystal x-ray diffraction techniques.